c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor Hadassa Waterman, Patent Attorney, Ehrlich & Fenster, 2001 Abstract: Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are negative regulators of ErbB. We report that ligand-induced degradation of internalized … Continue reading c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor